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UBE2K / LIG

ubiquitin-conjugating enzyme E2K

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

Gene Name: ubiquitin-conjugating enzyme E2K
Synonyms: UBE2K, E2-25K, E2(25K), HIP2, HYPG, LIG, UBC1, Ubiquitin-protein ligase, HIP-2, Ubiquitin carrier protein
Target Sequences: NM_005339 NP_005330.1 P61086

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Products
Proteins (12)
Over-Expression Lysate (4)
Recombinant (8)
UBE2K / LIG (12)
No (12)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (2)
His (2)
Myc-DDK (Flag) (5)
Human (10)
293T Cells (2)
E. coli (6)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (4)
UBE2K / LIG Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
16.4 kDa
100 µg/$494
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
34.5 kDa
10 µg/$322; 50 µg/$365
UBE2K / LIG Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
22.2 kDa
100 µg/$494
UBE2K / LIG Protein - 12.5% SDS-PAGE of human HIP2 stained with Coomassie Blue
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Wheat Germ Extract
GST
48.8 kDa
10 µg/$479; 25 µg/$670
UBE2K / LIG Protein
Select
E. coli
His
26.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
UBE2K / LIG Protein - Purified recombinant protein UBE2K was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
22.2 kDa
20 µg/$1,107
UBE2K / LIG Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
16.4 kDa
20 µg/$150
UBE2K / LIG Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
22.2 kDa
20 µg/$150
UBE2K / LIG Protein
Select
E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276; 20 µg/$332; 100 µg/$544; 500 µg/$1,473
Select
E. coli
6His-SUMO, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
34.5kD
10 µg/$233; 50 µg/$277; 500 µg/$725; 1 mg/$1,113
Select
E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.7kD
10 µg/$233; 50 µg/$266; 500 µg/$761; 1 mg/$1,067
Select
E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.7 kDa
10 µg/$322; 50 µg/$354
Viewing 1-12 of 12 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).