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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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UBE2I / UBC9
ubiquitin-conjugating enzyme E2I
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'.
| Gene Name: | ubiquitin-conjugating enzyme E2I |
| Synonyms: | UBE2I, C358B7.1, SUMO-conjugating enzyme UBC9, UBC9, SUMO-protein ligase, UBCE9, Ubiquitin carrier protein 9, Ubiquitin carrier protein I, Ubiquitin-protein ligase I, p18, SUMO-1-protein ligase, Ubiquitin conjugating enzyme 9, Ubiquitin-protein ligase E2I |
| Target Sequences: | NM_003345 NP_003336.1 P63279 |
Publications (1)
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