UBE2D3 / UBCH5C

ubiquitin-conjugating enzyme E2D 3

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.

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Products

Proteins (26)

Type

Over-Expression Lysate (16)

Recombinant (10)

Target

UBE2D3 / UBCH5C (26)

Publications

No (26)

Tag

GST (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (21)

Species

Human (18)

Source

293T Cells (8)

E. coli (4)

HEK 293 Cells (13)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85883

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$150

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Human UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85884

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$150

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Human UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85886

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$150

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Human UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85889

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$150

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Human UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85890

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.7 kDa

Price:

20 µg/$150

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Human UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85879

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$150

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Human UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85880

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$150

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Human UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85878

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$150

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Human UBE2D3 / UBCH5C Protein (Recombinant His-SUMO) (Full Length) - LS-G21305

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

32.7 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human UBE2D3 / UBCH5C Protein (Recombinant GST) (Full Length) - LS-G30817

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.91 kDa

Price:

10 µg/$479; 25 µg/$670

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Human UBE2D3 / UBCH5C Protein (Recombinant) (Met1-Met147) - LS-G39793

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.6kD

Price:

10 µg/$233; 50 µg/$277; 500 µg/$725; 1 mg/$1,113

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UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104334

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

100 µg/$494

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UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104336

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

100 µg/$494

Select

UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104335

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

100 µg/$494

Select

UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104337

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

100 µg/$494

Select

UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104338

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

100 µg/$494

Select

UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104339

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

100 µg/$494

Select

UBE2D3 / UBCH5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104341

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.7 kDa

Price:

100 µg/$494

Select

Human UBE2D3 / UBCH5C Protein (Recombinant) (Met1-Met147) - LS-G138705

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.6 kDa

Price:

10 µg/$322; 50 µg/$365

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Human UBE2D3 / UBCH5C Protein (Recombinant His) - LS-G1488

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human UBE2D3 / UBCH5C Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69933

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$1,107

Select

Human UBE2D3 / UBCH5C Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69934

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$1,107

Select

Human UBE2D3 / UBCH5C Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69935

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$1,107

Select

Human UBE2D3 / UBCH5C Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69937

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.7 kDa

Price:

20 µg/$1,107

Select

Human UBE2D3 / UBCH5C Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69936

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.5 kDa

Price:

20 µg/$1,107

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