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Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
Gene Name: | ubiquitin-conjugating enzyme E2D 2 |
Synonyms: | UBE2D2, E2(17)KB2, PUBC1, UBCH4, UBCH5B, UBC4/5, UBC5B, Ubiquitin carrier protein D2, UBC4, Ubiquitin-protein ligase D2 |
Target Sequences: | NM_003339 NP_003330.1 P62837 |
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