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UBE1L2 / UBE1L2
ubiquitin-like modifier activating enzyme 6
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
| Gene Name: | ubiquitin-like modifier activating enzyme 6 |
| Synonyms: | UBA6, FLJ10808, Monocyte protein 4, MOP-4, Ubiquitin-activating enzyme 6, E1-L2, MOP4, UBE1L2 |
| Target Sequences: | NM_018227 NP_060697.4 A0AVT1 |
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