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UBASH3B / STS-1
ubiquitin associated and SH3 domain containing B
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
| Gene Name: | ubiquitin associated and SH3 domain containing B |
| Synonyms: | UBASH3B, Cbl-interacting protein Sts-1, KIAA1959, p70, STS1, TULA-2, T-cell ubiquitin ligand 2, Cbl-interacting protein p70, STS-1 |
| Target Sequences: | NM_032873 NP_116262.2 Q8TF42 |
![UBASH3B / STS-1 Antibody - Immunoperoxidase of monoclonal antibody to UBASH3B on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/ubash3b-sts-1-antibody-clone-3g7-ls-c134114/53776_5189290.jpg)
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