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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TYRO3

TYRO3 protein tyrosine kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Gene Name: TYRO3 protein tyrosine kinase
Family/Subfamily: Protein Kinase , Axl
Synonyms: TYRO3, Brt, BYK, Dtk, Sky kinase, Sky, Tif, Tyrosine-protein kinase byk, Tyrosine-protein kinase SKY, Tyrosine-protein kinase DTK, TYRO3 protein tyrosine kinase, Tyrosine-protein kinase brt, RSE, Tyrosine-protein kinase RSE
Target Sequences: NM_006293 NP_006284.2 Q06418

Filtered by: None
Target
TYRO3 (47)
Reactivity
Human (45)
Mouse (12)
Rat (5)
Dog (1)
Horse (1)
Monkey (2)
Application
IHC (19)
IHC-P (10)
WB (33)
Flo (7)
ELISA (13)
ICC (10)
IF (19)
IP (15)
Peptide-ELISA (1)
RNAi (1)
Host
rabbit (22)
mouse (25)
Isotype
IgG (12)
IgG1 (13)
IgG1,k (1)
IgG2a (4)
IgG2a,k (1)
IgG2b (4)
Clonality
monoclonal mc (25)
polyclonal pc (22)
Clone
1444CT895.86.31 (1)
1C10E8, 9A3F2 (2)
1E+12 (2)
4F6 (1)
64CT15.6.2.3.1 (1)
6D6F10 (2)
OTI2C4 (2)
OTI2D11 (2)
OTI2G2 (2)
OTI4C8 (2)
OTI5B4 (2)
OTI5B7 (2)
OTI9B12 (2)
Format
Biotin Conjugated (2)
Carrier-free (7)
DY488 Conjugated (2)
DY550 Conjugated (2)
DY650 Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (38)
Epitope
aa100-250 (4)
aa842-873 (2)
Amino Acid: 138-321 (1)
Internal (1)
N-Terminus (1)
aa110-127 (1)
aa470-520 (1)
aa850-C-term (1)
aa854-878 (1)
Publications
No (47)
Showing 1-25 of 47 results

IHC-plus™ TYRO3 Antibody LS-B15188
Rabbit Polyclonal (IgG) to Human TYRO3
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg  $425.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
Immunohistochemistry of paraffin-embedded human lung tissue using TYRO3 Antibody at dilution of 1:100

TYRO3 Antibody (clone 64CT15.6.2.3.1) LS-C96489
Mouse Monoclonal [clone 64CT15.6.2.3.1] to Human TYRO3
Human
ICC, IF, IHC, IHC-P
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with TYRO3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Confocal immunofluorescence of TYRO3 Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).

TYRO3 Antibody LS-C99135
Rabbit Polyclonal to Human TYRO3
Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human brain tissue reacted with TYRO3 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of lysate from U-87 MG cell line, using TYRO3 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

TYRO3 Antibody (clone OTI2C4) LS-C114520
Mouse Monoclonal [clone OTI2C4] (IgG2b) to Human TYRO3
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100µl 1.3mg/ml  $345.00
IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI2C4, Carrier-free) LS-C784243
Mouse Monoclonal [clone OTI2C4] (IgG2b) to Human TYRO3
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone 6D6F10) LS-C109116
Mouse Monoclonal [clone 6D6F10] (IgG1) to Human TYRO3
Human
ELISA, IF
Unconjugated
100µl  $345.00
Immunofluorescence of HeLa (Left) and MCF-7 (Right) cells using Tyro3 mouse monoclonal antibody (green).

TYRO3 Antibody (clone OTI9B12) LS-C114525
Mouse Monoclonal [clone OTI9B12] (IgG1) to Human TYRO3
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded pancreas tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Carcinoma of pancreas tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI9B12, Carrier-free) LS-C784248
Mouse Monoclonal [clone OTI9B12] (IgG1) to Human TYRO3
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded pancreas tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Carcinoma of pancreas tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI2D11) LS-C114523
Mouse Monoclonal [clone OTI2D11] (IgG1) to Human TYRO3
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Kidney tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded pancreas tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI2D11, Carrier-free) LS-C784245
Mouse Monoclonal [clone OTI2D11] (IgG1) to Human TYRO3
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Kidney tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded pancreas tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody LS-C662491
Rabbit Polyclonal to Human TYRO3
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100µg  $325.00
Western blot - Anti-TYRO3 Picoband antibody

TYRO3 Antibody (clone OTI2G2) LS-C114524
Mouse Monoclonal [clone OTI2G2] (IgG2b) to Human TYRO3
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl 1.32mg/ml  $345.00
IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI2G2, Carrier-free) LS-C784246
Mouse Monoclonal [clone OTI2G2] (IgG2b) to Human TYRO3
Human
IHC, IP, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI5B4) LS-C114519
Mouse Monoclonal [clone OTI5B4] (IgG2a) to Human TYRO3
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI5B4, Carrier-free) LS-C784242
Mouse Monoclonal [clone OTI5B4] (IgG2a) to Human TYRO3
Human
IHC, IP, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI4C8) LS-C114522
Mouse Monoclonal [clone OTI4C8] (IgG1) to Human TYRO3
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl 1.3mg/ml  $345.00
IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded colon tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI4C8, Carrier-free) LS-C784240
Mouse Monoclonal [clone OTI4C8] (IgG1) to Human TYRO3
Human
IHC, IP, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded colon tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).

TYRO3 Antibody (clone OTI5B7) LS-C114521
Mouse Monoclonal [clone OTI5B7] (IgG2a) to Human TYRO3
Human
Flo, IF, IP
Unconjugated
100µl 1mg/ml  $345.00
Anti-TYRO3 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TYRO3.
HEK293T cells transfected with either pCMV6-ENTRY TYRO3 (Red) or empty vector control plasmid (Blue) were immunostained with anti-TYRO3 mouse monoclonal(Dilution 1:1,000), and then analyzed by flow cytometry.

TYRO3 Antibody (clone OTI5B7, Carrier-free) LS-C784244
Mouse Monoclonal [clone OTI5B7] (IgG2a) to Human TYRO3
Human
Flo, IF, IP
Unconjugated, Carrier-free
100µg  $395.00
Anti-TYRO3 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TYRO3.
HEK293T cells transfected with either pCMV6-ENTRY TYRO3 (Red) or empty vector control plasmid (Blue) were immunostained with anti-TYRO3 mouse monoclonal(Dilution 1:1,000), and then analyzed by flow cytometry.

TYRO3 Antibody (clone 1C10E8, 9A3F2) LS-C758703
Mouse Monoclonal [clone 1C10E8, 9A3F2] (IgG1) to Human TYRO3
Human
ICC, IF, WB
Unconjugated
100µl  $425.00
TYRO3 Antibody in Immunofluorescence (IF)
TYRO3 Antibody in Western Blot (WB)

TYRO3 Antibody (Internal) LS-C142734
Rabbit Polyclonal to Human TYRO3
Mouse, Human
ICC, IF, WB
Unconjugated
100µl  $335.00
TYRO3 Antibody - Lane 1: Western blot on normal human brain, Lane 2: Western blot on normal mouse brain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TYRO3 Antibody (clone 1C10E8, 9A3F2) LS-C47224
Mouse Monoclonal [clone 1C10E8, 9A3F2] (IgG1) to Human TYRO3
Human
ELISA, IF, WB
Unconjugated
100µg  $345.00
Immunofluorescence Image
Western blot Image

TYRO3 Antibody (aa842-873) LS-C328985
Rabbit Polyclonal (IgG) to Human TYRO3
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

TYRO3 Antibody (aa842-873) LS-C99134
Rabbit Polyclonal to Human TYRO3
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of SKY (arrow) using rabbit polyclonal SKY Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SKY gene (Lane 2) (Origene Technologies).

TYRO3 Antibody (clone 4F6) LS-C198389
Mouse Monoclonal [clone 4F6] (IgG2a,k) to Human TYRO3
Human
ELISA, RNAi, WB
Unconjugated
100µg  $365.00
Western Blot analysis of TYRO3 expression in transfected 293T cell line by TYRO3 monoclonal antibody (M05), clone 4F6.Lane 1: TYRO3 transfected lysate(96.9 KDa).Lane 2: Non-transfected lysate.
Detection limit for recombinant GST tagged TYRO3 is approximately 0.1 ng/ml as a capture antibody.
Showing 1-25 of 47 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).