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TWIST1 / TWIST
twist family bHLH transcription factor 1
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.
| Gene Name: | twist family bHLH transcription factor 1 |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | TWIST1, ACS3, Acrocephalosyndactyly 3, B-HLH DNA binding protein, BHLHa38, BPES2, BPES3, CRS1, SCS, TWIST, H-twist, Twist homolog 1 (Drosophila), TWIST homolog of drosophila, Twist-related protein 1 |
| Target Sequences: | NM_000474 NP_000465.1 Q15672 |
Publications (3)
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