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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TWIST1 / TWIST

twist family bHLH transcription factor 1

Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.

Gene Name: twist family bHLH transcription factor 1
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: TWIST1, ACS3, Acrocephalosyndactyly 3, B-HLH DNA binding protein, BHLHa38, BPES2, BPES3, CRS1, SCS, TWIST, H-twist, Twist homolog 1 (Drosophila), TWIST homolog of drosophila, Twist-related protein 1
Target Sequences: NM_000474 NP_000465.1 Q15672

Publications (3)

1
The expression of twist in differentiated thyroid carcinomas. Calangiu CM, Margaritescu C, Cernea D, Stepan A, Simionescu CE. Current health sciences journal. 2015 40:184-9. (IHC; Human) [Full Text Article] [PubMed:25729603] [PMC:PMC4340438] Related Antibodies: LS-C191858.
2
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112]
3
Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1. Zhou W, Thiery JP. Journal of cell science. 2013 Jun;126:2740-6. [Full Text Article] [PubMed:23591815] Related Antibodies: LS-C30601.

☰ Filters
Viewing 1-6 of 6 items
TWIST1 / TWIST Protein - Purified recombinant protein TWIST1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc + DDK
20.8 kDa
20µg   $890.00
TWIST1 / TWIST Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
20.8 kDa
20µg   $195.00
TWIST1 / TWIST Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST,N-terminus
10µg   $425.00; 25µg   $590.00
TWIST1 / TWIST Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST,N-terminus
10µg   $425.00; 25µg   $590.00
TWIST1 / TWIST Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
20.8 kDa
100µg   $365.00
TWIST1 / TWIST Protein - 12.5% SDS-PAGE of human TWIST1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
47.85 kDa
10µg   $425.00; 25µg   $590.00

Viewing 1-6 of 6 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).