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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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TWIST1 / TWIST

twist family bHLH transcription factor 1

Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.

Gene Name: twist family bHLH transcription factor 1
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: TWIST1, ACS3, Acrocephalosyndactyly 3, B-HLH DNA binding protein, BHLHa38, BPES2, BPES3, CRS1, SCS, TWIST, H-twist, Twist homolog 1 (Drosophila), TWIST homolog of drosophila, Twist-related protein 1
Target Sequences: NM_000474 NP_000465.1 Q15672

Publications (3)

1
The expression of twist in differentiated thyroid carcinomas. Calangiu CM, Margaritescu C, Cernea D, Stepan A, Simionescu CE. Current health sciences journal. 2015 40:184-9. (IHC; Human) [Full Text Article] [PubMed:25729603] [PMC:PMC4340438] Related Antibodies: LS-C191858.
2
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112]
3
Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1. Zhou W, Thiery JP. Journal of cell science. 2013 Jun;126:2740-6. [Full Text Article] [PubMed:23591815] Related Antibodies: LS-C30601.

Viewing 1-25 of 45 items
TWIST1 / TWIST Antibody - Anti-TWIST1 / TWIST antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Rabbit Polyclonal to Human TWIST1 / TWIST
Human
IHC, IHC-P, WB
Unconjugated
100µl   $425.00
TWIST1 / TWIST Antibody - IHC of paraffin-embedded cervical cancer tissues using TWIST1 mouse monoclonal antibody with DAB staining.
Select
(1) Publication(s)
Mouse Monoclonal [clone 10E4E6] (IgG1) to Human TWIST1 / TWIST
Mouse, Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100µg   1mg/ml   $365.00
TWIST1 / TWIST Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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(1) Publication(s)
Rabbit Polyclonal (IgG) to Human TWIST1 / TWIST
Xenopus, Chicken, Zebrafish, Pig, Horse, Mouse, Rat, Bovine, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $335.00
TWIST1 / TWIST Antibody - Western blot analysis of TWIST expression in Jurkat (A); Raw264.7 (B); rat liver (C) whole cell lysates.
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Rabbit Polyclonal to Human TWIST1 / TWIST
Mouse, Rat, Human
WB
Unconjugated
100µl   1mg/ml   $245.00
TWIST1 / TWIST Antibody - Immunofluorescence analysis of MCF7 cell using TWIST1 antibody. Blue: DAPI for nuclear staining.
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Rabbit Polyclonal (IgG) to Human TWIST1 / TWIST
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl   $235.00; 100µl   $315.00; 200µl   $425.00
TWIST1 / TWIST Antibody - Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-TWIST mAb.
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Mouse Monoclonal [clone Twist2C1a] (IgG1) to Human TWIST1 / TWIST
Mouse, Rat, Human
DB, Flo, ICC, IF, WB
Unconjugated
100µg   100µg/ml   $415.00
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Mouse Monoclonal (IgG1) to Human TWIST1 / TWIST
Mouse, Rat, Human
ELISA, Flo, ICC, WB
Unconjugated
50µg   $435.00
Select
Sheep Polyclonal (IgG) to Human TWIST1 / TWIST
Human
Flo
APC Conjugated
100tst   $755.00
TWIST1 / TWIST Antibody - Immunofluorescent staining using TWIST antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-TWIST antibody.
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Mouse Monoclonal [clone Twist2C1a] (IgG1) to Human TWIST1 / TWIST
Mouse, Rat, Human
DB, Flo, ICC, WB
Unconjugated
100µg   $560.00
TWIST1 / TWIST Antibody - TWIST1 monoclonal antibody (M01), clone 3E11. Western Blot analysis of TWIST1 expression in rat brain.
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Mouse Monoclonal [clone 3E11] (IgG1,k) to Human TWIST1 / TWIST
Rat, Human
ELISA, IP, RNAi, WB
Unconjugated
100µg   $365.00
Select
Rabbit Polyclonal to Human TWIST1 / TWIST
Human
ELISA, IHC, WB
Unconjugated
100µg   100µl   1mg/ml   $315.00
Select
Rabbit Polyclonal to Human TWIST1 / TWIST
Mouse, Rat, Human
IHC, WB
Unconjugated
100µg   $305.00
Select
Rabbit Polyclonal (IgG) to Human TWIST1 / TWIST
Human
ELISA, IP, WB
Unconjugated
100µg   $465.00
Select
Mouse Monoclonal (IgG1) to Human TWIST1 / TWIST
Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
TWIST1 / TWIST Antibody - Western blot using TWIST1 monoclonal antibody against human TWIST1 recombinant protein. (Expected MW is 40 kDa)
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Mouse Monoclonal [clone 2F8E7] (IgG2b) to Human TWIST1 / TWIST
Human
ELISA, WB
Unconjugated
100µg   1mg/ml   $365.00
Select
Rabbit Polyclonal (IgG) to Human TWIST1 / TWIST
Human
ELISA, WB
Unconjugated
100µg   $435.00
Select
Rabbit Polyclonal to Human TWIST1 / TWIST
Mouse, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
TWIST1 / TWIST Antibody
Select
Rabbit Polyclonal (IgG) to Human TWIST1 / TWIST
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
TWIST1 / TWIST Antibody - Positive Western Blot detected in MCF-7 whole cell lysate. All lanes: TWIST1 antibody at 3 µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 21 KDa. Observed band size: 50 KDa
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Rabbit Polyclonal (IgG) to Human TWIST1 / TWIST
Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
TWIST1 / TWIST Antibody - Western blot analysis of lysates from Jurkat cells , using Twist antibody.
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Rabbit Polyclonal (IgG) to Human TWIST1 / TWIST
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
TWIST1 / TWIST Antibody - Western blot blot of extracts of various cell lines, using TWIST1 antibody.
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Rabbit Polyclonal (IgG) to Human TWIST1 / TWIST
Human
IP, WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00
TWIST1 / TWIST Antibody - TWIST1 Antibody in Western Blot (WB)
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Mouse Monoclonal [clone 2F8E7] (IgG2b) to Human TWIST1 / TWIST
Human
WB
Unconjugated
100µg   $405.00
TWIST1 / TWIST Antibody - Immunochemical staining of mouse TWIST1 in mouse uterus with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
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Rabbit Polyclonal (IgG) to Mouse TWIST1 / TWIST
Mouse
IHC-P
Unconjugated, Preservative Free
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
Select
Rabbit Polyclonal to Human TWIST1 / TWIST
Mouse, Rat, Human
WB
Unconjugated
100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human TWIST1 / TWIST
Human
WB
Unconjugated
50µl   $345.00

Viewing 1-25 of 45 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).