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TULP3
tubby like protein 3
TULP3 is a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene.
| Gene Name: | tubby like protein 3 |
| Synonyms: | TULP3, Tubby-related protein 3, TUBL3, Tubby like protein 3, Tubby-like protein 3 |
| Target Sequences: | NM_003324 NP_003315.2 O75386 |
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