TTN / Titin

Titin

TTN / Titin is a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

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Proteins (6)

Type

Recombinant (6)

Target

TTN / Titin (6)

Publications

No (6)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, N-terminus (1)

GST (1)

GST, N-terminus (2)

His (1)

Species

Human (6)

Source

E. coli (3)

Wheat Germ Extract (3)

Purification

Purified (2)

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Human TTN / Titin Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa14257-14543) - LS-G56606

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Price:

1 mg/$1,486; 100 µg/$451; 20 µg/$339

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Human TTN / Titin Protein (Recombinant 6His, N-terminus) (aa5398-5604) - LS-G22657

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

27.2 kD

Price:

1 mg/$1,486; 100 µg/$451; 20 µg/$339

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Human TTN / Titin Protein (Recombinant His) (aa33779-34025) - LS-G14126

Source:

E. coli

Tag:

His

Molecular Weight:

28.3 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Human TTN / Titin Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G60441

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TTN / Titin Protein (Recombinant GST, N-terminus) (aa26827-26926) - LS-G60442

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TTN / Titin Protein (Recombinant GST) (Full Length) - LS-G30788

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

59.2 kDa

Price:

10 µg/$479; 25 µg/$670

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