TTN / Titin

Titin

TTN / Titin is a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

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ELISA Kits (13)

Type

Custom (1)

Development Kit (1)

Sandwich (10)

Sandwich CLIA (1)

Target

TTN / Titin (13)

Reactivity

Human (7)

Mouse (1)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Product Group

DevKit DuoPlus (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (10)

Antibody Pair and Standard (1)

Publications

No (13)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (3)

Plasma (4)

Saliva (1)

Serum (5)

Tissue Homogenates (3)

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Human TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F35134

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$579

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Mouse TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F18267

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F4893

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Human TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F20925

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Saliva, Serum

Price:

1 Plate/$651

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Human TTN / Titin (CLIA) ELISA Kit - LS-F29394

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Human TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F52774

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

23.5 - 1500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

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Guinea pig TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F48635

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F48636

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Chicken TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F48637

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F48639

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine TTN / Titin (Sandwich ELISA) ELISA Kit - LS-F48638

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Human TTN / Titin (Custom ELISA) ELISA Kit - LS-F18266

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

DevKit DuoPlus Human TTN / Titin ELISA Development Kit - LS-F71766

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,229; 1000 Wells/$1,826

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