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TTI2 / C8orf41
TELO2 interacting protein 2
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.
| Gene Name: | TELO2 interacting protein 2 |
| Synonyms: | TTI2, C8orf41, TELO2-interacting protein 2, TELO2 interacting protein 2 |
| Target Sequences: | NM_025115 NP_079391.2 Q6NXR4 |
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