TTF / RHOH

ras homolog family member H

Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca2+ mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

TTF / RHOH (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human TTF / RHOH Protein (Recombinant GST) (Full Length) - LS-G27523

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.75 kDa

Price:

2 µg/$439

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TTF / RHOH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100256

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.1 kDa

Price:

100 µg/$494

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Human TTF / RHOH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76322

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.1 kDa

Price:

20 µg/$150

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