TTC3

tetratricopeptide repeat domain 3

E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

TTC3 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human TTC3 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G60437

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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TTC3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122734

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

229.7 kDa

Price:

100 µg/$710

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Human TTC3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79200

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

229.7 kDa

Price:

20 µg/$215

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