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TSPAN20 / UPK1B
Uroplakin 1b
TSPAN20 / UPK1B is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.
| Gene Name: | Uroplakin 1b |
| Family/Subfamily: | Tetraspan , not assigned-Tetraspan |
| Synonyms: | UPK1B, Uroplakin 1B, Uroplakin Ib, TETRASPAN, UPK1, Tetraspanin-20, TSPAN20, Tspan-20, UP1b, UPIB, Uroplakin-1b |
| Target Sequences: | NM_006952 NP_008883.2 O75841 |
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