TSPAN12

tetraspanin 12

Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

TSPAN12 (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

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Human TSPAN12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89725

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.2 kDa

Price:

20 µg/$150

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Human TSPAN12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71423

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.2 kDa

Price:

20 µg/$1,107

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TSPAN12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101085

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.2 kDa

Price:

100 µg/$494

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