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TSLP

thymic stromal lymphopoietin

TSLP is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.

Gene Name: thymic stromal lymphopoietin
Family/Subfamily: Cytokine
Synonyms: TSLP, Thymic stromal lymphopoietin
Target Sequences: NM_033035 NP_149024.1 Q969D9

Publications (4)

1
Keratin-dependent thymic stromal lymphopoietin expression suggests a link between skin blistering and atopic disease. Kumar V, Behr M, Kiritsi D, Scheffschick A, Grahnert A, Homberg M, Schwieger-Briel A, Jakob T, Bruckner-Tuderman L, Magin TM. The Journal of allergy and clinical immunology. 2016 138:1461-1464. (WB; Human) [Full Text Article] [PubMed:27527262] Related Antibodies: LS-B3208.
2
Increased expression of epidermal thymic stromal lymphopoietin in inflammatory peeling skin syndrome. Taizo Wada, Tomoko Toma, Yasuhito Hamaguchi, Akihiro Yachie. The Journal of dermatology. 2014 May;41:448-9. [Full Text Article] [PubMed:24628284] Related Antibodies: LS-B3208.
3
Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor beta . Christmann RB, Mathes A, Affandi AJ, Padilla C, Nazari B, Bujor AM, Stifano G, Lafyatis R. Arthritis and rheumatism. 2013 May;65:1335-46. (IHC; Mouse) [Full Text Article] [PubMed:23335246] Related Antibodies: LS-B3208.
4
Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa. Wang W, Li Y, Lv Z, Chen Y, Li Y, Huang K, Corrigan CJ, Ying S. Journal of immunology (Baltimore, Md. : 1950). 2018 October;201:2221-2231. [Full Text Article] [PubMed:30185520] Related Antibodies: LS-B614.
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Products
Antibodies (66)
Primary (66)
TSLP (66)
Human (44)
Mouse (17)
Rat (13)
Gibbon (3)
Horse (3)
Monkey (3)
IHC (6)
IHC-P (8)
WB (58)
Flo (2)
ELISA (18)
IF (2)
Peptide-ELISA (1)
rabbit (61)
mouse (5)
Product Group
IHCPlus (6)
IgG (25)
IgG1,k (1)
IgG2a,k (3)
monoclonal mc (5)
polyclonal pc (61)
55N1D10 (1)
55N1E3 (1)
55N2D4 (1)
APC (3)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (9)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (6)
HRP Conjugated (6)
Liquid (1)
Lyophilized (1)
PE Conjugated (4)
Unconjugated (31)
aa21-138 (8)
aa25-146 (8)
aa29-159 (8)
aa101-130 (7)
aa89-138 (4)
aa27-158 (1)
No (64)
Yes (2)
TSLP Antibody - Anti-TSLP antibody IHC of human brain, cortex pyramidal cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TSLP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
TSLP Antibody - Anti-TSLP antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TSLP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
TSLP Antibody - Anti-TSLP antibody IHC of mouse liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TSLP Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
TSLP Antibody - Immunohistochemistry-Paraffin: TSLP Antibody (55N2D4) - Formalin-fixed, paraffin-embedded normal human kidney stained with TSLP antibody (3 ug/ml), peroxidase-conjugate and DAB chromogen. tissue array slide was used for this test.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSLP Mouse anti-Human Monoclonal (55N2D4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.1 mg/$386
TSLP Antibody - Immunohistochemistry-Paraffin: TSLP Antibody (55N1D10) - Formalin-fixed, paraffin-embedded normal human spleen (top) and human lung carcinoma (bottom) stained with TSLP antibody (1 ug/ml), peroxidase-conjugate and DAB chromogen.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSLP Mouse anti-Human Monoclonal (aa27-158) (55N1D10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.1 mg/$386
TSLP Antibody - Western Blot (non-reducing) of TSLP antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSLP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
TSLP Antibody - Western Blot (non-reducing) of TSLP antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSLP Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
TSLP Antibody - Fig-1: Western blot analysis of TSLP. Anti-TSLPin antibody was used at 4 µg/ml on hHeart, hSKM and mouse embryonic Liver lysates.
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TSLP Mouse anti-Human Monoclonal Antibody
Mouse, Human
Flo, WB
Unconjugated
25 µg/$288; 100 µg/$414
TSLP Antibody - TSLP antibody Western blot of MCF7 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSLP Rabbit anti-Human Polyclonal (aa89-138) Antibody
Human
WB
Unconjugated
100 µl/$424
TSLP Antibody - TSLP antibody Western blot of MCF7 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSLP Rabbit anti-Human Polyclonal (aa89-138) (Biotin) Antibody
Horse, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
TSLP Antibody - Western Blot: TSLP Antibody (55N1E3) - Analysis of TSLP partial recombinant protein (amino acids 27-158) using TSLP antibody at 0.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSLP Mouse anti-Human Monoclonal (55N1E3) Antibody
Human
WB
Unconjugated
0.1 mg/$386
TSLP Antibody - TSLP Antibody western blot of Jurkat cell line lysates (35 ug/lane). The TSLP antibody detected the TSLP protein (arrow).
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TSLP Rabbit anti-Human Polyclonal (aa101-130) Antibody
Human
WB
Unconjugated
400 µl/$393
TSLP Antibody - Immunohistochemistry of paraffin-embedded human prostate tissue using TSLP Antibody at dilution of 1:100
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TSLP Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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TSLP Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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TSLP Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
TSLP Antibody - Western blot of TSLP antibody.
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TSLP Rabbit anti-Human Polyclonal (aa29-159) Antibody
Human
WB
Unconjugated
100 µl/$275; 200 µl/$302; 500 µl/$393; 1 ml/$439; 2 ml/$530; 5 ml/$894
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TSLP Rabbit anti-Human Polyclonal (aa101-130) (Azide-free) (HRP) Antibody
Human
WB
HRP Conjugated, Azide-free
200 µl/$952
TSLP Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TSLP Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
TSLP Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TSLP Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
TSLP Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TSLP Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
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TSLP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$351
TSLP Antibody - Fig-1: Western blot analysis of TSLP. Anti-TSLP antibody was used at 2 µg/ml on (1) h Heart and (2) h Liver lysates.
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TSLP Mouse anti-Human Monoclonal Antibody
Human
Flo, WB
Unconjugated
25 µg/$288; 100 µg/$414
TSLP Antibody - Western Blot of Rabbit anti-TSLP antibody. Lane 1: Human TSLP Recombinant Protein. Lane 2: None. Load: 50 ng per lane. Primary antibody: TSLP antibody at 1:1,000 for overnight at 4 degrees C. Secondary antibody: DyLight alpha 649 rabbit secondary antibody at 1:20,000 for 30 min at RT. Block: MB-070 for 30 min at RT. Predicted/Observed size: 13 kDa, 13 kDa for Human TSLP. Other band(s): None.
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TSLP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$567
TSLP Antibody - Western blot - Anti-TSLP Picoband Antibody
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TSLP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
TSLP Antibody - Western Blot of rabbit anti-TSLP antibody. Lane 1: Human TSLP Recombinant Protein. Lane 2: None. Load: 50 ng per lane. Primary antibody: TSLP antibody at 1:1,000 for overnight at 4°C. Secondary antibody: DyLight 649 rabbit secondary antibody at 1:20,000 for 30 min at RT. Block: MB-070 for 30 min at RT. Predicted/Observed size: 13 kDa, 13 kDa for Human TSLP. Other band(s): None.
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TSLP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
25 µl/$304
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).