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TSHB / TSH-Beta

thyroid stimulating hormone, beta

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants.

Gene Name: thyroid stimulating hormone, beta
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: TSHB, Thyrotropin alfa, Thyrotropin beta subunit, TSH Beta, TSH-B, Thyrotropin beta chain, Thyrotropin subunit beta, TSH-BETA, CHNG4
Target Sequences: NM_000549 NP_000540.2 P01222

Publications (2)

1
MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA. The Journal of biological chemistry. 2010 285:34718-28. (IHC-P; Mouse) [PubMed:20807761] [PMC:PMC2966087]
2
Thyroid hormone receptor ß sumoylation is required for thyrotropin regulation and thyroid hormone production. Sujie Ke , Yan-Yun Liu, Rajendiran Karthikraj, Kurunthachalam Kannan, Jingjing Jiang , Kiyomi Abe , Anna Milanesi, Gregory A Brent. JCI insight. 2021 Aug;6:e149425. [Full Text Article] [PubMed:34237030] [PMC:PMC8410017] Related Antibodies: LS-C334949.

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Products
Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
TSHB / TSH-Beta (10)
No (10)
10His, N-terminus + Myc, C-terminus (1)
6His, N-terminus (1)
6His, N-terminus + Myc, C-terminus (1)
His (1)
His, N-Terminal (1)
His-GST-S (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Chicken (1)
Dog (1)
Human (4)
Mouse (1)
Rat (2)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Yeast (1)
Purified (3)
TSHB / TSH-Beta Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus + Myc, C-terminus
19.9 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
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E. coli
6His, N-terminus
14.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
TSHB / TSH-Beta Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus + Myc, C-terminus
16.4 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
TSHB / TSH-Beta Protein
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E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
TSHB / TSH-Beta Protein - Purified recombinant protein TSHB was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
13.5 kDa
20 µg/$1,107
TSHB / TSH-Beta Protein
Select
E. coli
His-SUMO
28.89 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TSHB / TSH-Beta Protein - Recombinant  Thyroid Stimulating Hormone Beta By SDS-PAGE
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E. coli
His-GST-S
43.7 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
TSHB / TSH-Beta Protein - Recombinant Thyroid Stimulating Hormone Beta (TSHb) by SDS-PAGE
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E. coli
His, N-Terminal
18.7kDa
10 µg/$278; 50 µg/$422; 200 µg/$842; 100 µg/$672; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
TSHB / TSH-Beta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
15.61 kDa
100 µg/$494
TSHB / TSH-Beta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
15.61 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).