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TSH Receptor / TSHR

thyroid stimulating hormone receptor

Thyrotropin Receptor, a Glycoprotein Hormone Receptor, plays a central role in controlling thyroid cell metabolism. The TSH receptor can interact with both TSH and autoantibodies against the TSH receptor (thyroid-stimulating immunoglobulins, TSI). Mutations in the receptor are the cause for hyperthyroidism such as gestational hyperthyroidism (hypersensitivity to chorionic gonadotropin) and Grave's disease (autoimmune hyperthyroidism). Multiple isoforms of the thyrotropin receptor are produced by altervative splicing.

Gene Name: thyroid stimulating hormone receptor
Family/Subfamily: GPCR , Glycoprotein hormone
Synonyms: TSHR, CHNG1, HTSHR-I, LGR3, Thyrotrophin receptor, TSH-R, TSH receptor, Thyrotropin receptor
Target Sequences: NM_000369 NP_000360.2 P16473

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).