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TSG101
tumor susceptibility 101
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.
| Gene Name: | tumor susceptibility 101 |
| Synonyms: | TSG101, ESCRT-I complex subunit TSG101, Tumor susceptibility gene 10, Tumor susceptibility protein, VPS23, Tumor susceptibility gene 101, TSG10 |
| Target Sequences: | NM_006292 NP_006283.1 Q99816 |
Publications (4)
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