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TSEN2

TSEN2 tRNA splicing endonuclease subunit

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

Gene Name: TSEN2 tRNA splicing endonuclease subunit
Synonyms: TSEN2, HsSen2, TRNA-intron endonuclease Sen2, PCH2B, SEN2, SEN2L
Target Sequences: NM_025265 NP_079541.1 Q8NCE0

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Products
Proteins (12)
Over-Expression Lysate (8)
Recombinant (4)
TSEN2 (12)
No (12)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (10)
Human (8)
293T Cells (4)
HEK 293 Cells (6)
Wheat Germ Extract (2)
Purified (1)
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
46.9 kDa
100 µg/$494
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
53.1 kDa
100 µg/$494
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
45.4 kDa
100 µg/$494
TSEN2 Protein - 12.5% SDS-PAGE of human TSEN2 stained with Coomassie Blue
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Wheat Germ Extract
GST
79.6 kDa
10 µg/$479; 25 µg/$670
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
53.1 kDa
100 µg/$494
TSEN2 Protein - Purified recombinant protein TSEN2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.1 kDa
20 µg/$1,107
TSEN2 Protein - Purified recombinant protein TSEN2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
53.1 kDa
20 µg/$1,107
TSEN2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
53.1 kDa
20 µg/$150
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
46.9 kDa
20 µg/$150
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
45.4 kDa
20 µg/$150
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
53.1 kDa
20 µg/$150
Viewing 1-12 of 12 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).