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TSEN2

TSEN2 tRNA splicing endonuclease subunit

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

Gene Name: TSEN2 tRNA splicing endonuclease subunit
Synonyms: TSEN2, HsSen2, TRNA-intron endonuclease Sen2, PCH2B, SEN2, SEN2L
Target Sequences: NM_025265 NP_079541.1 Q8NCE0

☰ Filters
Antibodies (20)
Proteins (12)
Over-Expression Lysate (8)
Primary (20)
Recombinant (4)
TSEN2 (32)
Human (20)
Mouse (4)
Rat (4)
Bat (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Horse (3)
Monkey (3)
Rabbit (3)
IHC (6)
IHC-P (1)
WB (19)
ELISA (12)
IF (2)
Peptide-ELISA (1)
rabbit (20)
IgG (14)
polyclonal pc (20)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (12)
aa16-43 (7)
aa395-444 (4)
aa1-220 (1)
No (32)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (10)
Human (8)
293T Cells (4)
HEK 293 Cells (6)
Wheat Germ Extract (2)
Purified (1)
TSEN2 Antibody - Immunofluorescence analysis of A549 cells.
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TSEN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TSEN2 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100
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TSEN2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
TSEN2 Antibody - Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue  using TSEN2 Polyclonal Antibody at dilution of 1:80(×200)
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TSEN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TSEN2 Antibody - Western blot. All lanes: TSEN2 antibody at 5 ug/ml+293T whole cell lysate. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 53 kDa. Observed band size: 53 kDa.
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TSEN2 Rabbit anti-Human Polyclonal (aa1-220) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µl/$294; 100 µl/$360
TSEN2 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TSEN2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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TSEN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TSEN2 Antibody - Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue  using TSEN2 Polyclonal Antibody at dilution of 1:60(×200)
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TSEN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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TSEN2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
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TSEN2 Rabbit anti-Human Polyclonal (aa16-43) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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TSEN2 Rabbit anti-Human Polyclonal (aa16-43) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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TSEN2 Rabbit anti-Human Polyclonal (aa16-43) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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TSEN2 Rabbit anti-Human Polyclonal (aa16-43) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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TSEN2 Rabbit anti-Human Polyclonal (aa16-43) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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TSEN2 Rabbit anti-Human Polyclonal (aa16-43) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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TSEN2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
TSEN2 Antibody - TSEN2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSEN2 Rabbit anti-Human Polyclonal (aa395-444) Antibody
Human
WB
Unconjugated
100 µl/$424
TSEN2 Antibody - TSEN2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSEN2 Rabbit anti-Human Polyclonal (aa395-444) (HRP) Antibody
Rabbit, Dog, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100 µl/$469
TSEN2 Antibody - TSEN2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSEN2 Rabbit anti-Human Polyclonal (aa395-444) (Biotin) Antibody
Rabbit, Dog, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
TSEN2 Antibody - TSEN2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TSEN2 Rabbit anti-Human Polyclonal (aa395-444) (FITC) Antibody
Rabbit, Dog, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$469
TSEN2 Antibody - TSEN2 Antibody western blot of HeLa cell line lysates (35 ug/lane). The TSEN2 antibody detected the TSEN2 protein (arrow).
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TSEN2 Rabbit anti-Human Polyclonal (aa16-43) Antibody
Human
WB
Unconjugated
400 µl/$393
TSEN2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TSEN2 Protein - Purified recombinant protein TSEN2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.1 kDa
20 µg/$1,107
TSEN2 Protein - Purified recombinant protein TSEN2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.1 kDa
20 µg/$1,107
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
53.1 kDa
20 µg/$150
TSEN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
46.9 kDa
20 µg/$150
Viewing 1-25 of 32 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).