TS / Thymidylate Synthase

thymidylate synthetase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

TS / Thymidylate Synthase (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human TS / Thymidylate Synthase Protein (Recombinant His-S) (aa36-313) - LS-G25816

Source:

E. coli

Tag:

His-S

Molecular Weight:

35.6 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human TS / Thymidylate Synthase Protein (Recombinant GST, N-terminus) (aa111-210) - LS-G60454

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TS / Thymidylate Synthase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86038

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

20 µg/$150

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Human TS / Thymidylate Synthase Protein (Recombinant GST) (Full Length) - LS-G30806

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TS / Thymidylate Synthase Protein (Recombinant His, N-Terminal) - LS-G142333

Source:

Sf9 Cells

Tag:

His, N-Terminal

Molecular Weight:

36 kDa

Price:

20 µg/$677

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Human TS / Thymidylate Synthase Protein (Recombinant His) - LS-G667

Source:

E. coli

Tag:

His

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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TS / Thymidylate Synthase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119317

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

100 µg/$494

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Human TS / Thymidylate Synthase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70001

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

20 µg/$1,107

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