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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TS / Thymidylate Synthase

thymidylate synthetase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Gene Name: thymidylate synthetase
Synonyms: TYMS, HST422, Thymidylate synthetase, TMS, TS, Thymidylate synthase, Tsase
Target Sequences: NM_001071 NP_001062.1 P04818

Publications (1)

1
Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. Haqqani AS, Cowling RT, Maroun JA, Birnboim HC. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1999 47:1563-74. [PubMed:10567440]

Filtered By: None
Type
Over-Expression Lysate (2)
Recombinant (6)
Target
TS / Thymidylate Synthase (8)
Tag
GST (1)
GST,N-terminus (1)
His (2)
His + S (1)
Myc + DDK (3)
Species
Human (7)
Source
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purification
Purified (3)
Showing 1-8 of 8 results

TS / Thymidylate Synthase Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G119317
HEK 293 Cells
365 AA
Myc + DDK
35.5 kDa
100µg  $345.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human TS / Thymidylate Synthase Protein (Recombinant Myc + DDK) (Full Length) - LS-G70001
HEK 293 Cells
365 AA
Myc + DDK
35.5 kDa
20µg  $815.00
Purified recombinant protein TYMS was analyzed by SDS-PAGE gel and Coomassie Blue Staining

Human TS / Thymidylate Synthase Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G86038
293T Cells
365 AA
Myc + DDK
35.5 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human TS / Thymidylate Synthase Protein (Recombinant GST) (Full Length) - LS-G30806
Wheat Germ Extract
313 AA
GST
62.1 kDa
10µg  $415.00; 25µg  $590.00
12.5% SDS-PAGE of human TYMS stained with Coomassie Blue

Human TS / Thymidylate Synthase Protein (Recombinant GST,N-terminus) (aa111-210) - LS-G60454
Wheat Germ Extract
100 AA
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human TS / Thymidylate Synthase Protein (Recombinant His + S) (aa36-313) - LS-G25816
E. coli
His + S
35.6 kDa
10µg  $275.00; 50µg  $445.00; 100µg  $590.00; 200µg  $860.00; 1mg  $2,205.00
Recombinant  Thymidylate Synthetase By SDS-PAGE

Human TS / Thymidylate Synthase Protein (Recombinant His) - LS-G667
E. coli
333 AA
His
100µg 1mg/ml  $295.00; 0.5mg 1mg/ml  $605.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human TS / Thymidylate Synthase Protein (Recombinant His) (aa1-313) - LS-G17689
E. coli
333 AA
His
5µg  $195.00; 25µg  $255.00; 1mg  $2,355.00
Showing 1-8 of 8 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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