Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

TS / Thymidylate Synthase

thymidylate synthetase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Gene Name: thymidylate synthetase
Synonyms: TYMS, HST422, Thymidylate synthetase, TMS, TS, Thymidylate synthase, Tsase
Target Sequences: NM_001071 NP_001062.1 P04818

Publications (2)

1
Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. Haqqani AS, Cowling RT, Maroun JA, Birnboim HC. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1999 47:1563-74. [PubMed:10567440]
2
Calpain 9 as a therapeutic target in TGFß-induced mesenchymal transition and fibrosis. David H Kim, James D Beckett, Varun Nagpal, Manuel A Seman-Senderos, Russell A Gould, Tyler J Creamer, Elena Gallo MacFarlane, Yichun Chen, Djahida Bedja, Jonathan T Butcher, Wayne Mitzner, Rosanne Rouf, Shoji Hata, Daniel S Warren, Harry C Dietz. Science translational medicine. 2019 Jul;11:eaau2814. [Full Text Article] [PubMed:31316008] [PMC:PMC7351287] Related Antibodies: LS-C133503.

☰ Filters
Products
ELISA Kits (12)
Custom (3)
Development Kit (1)
Sandwich (7)
Sandwich CLIA (1)
TS / Thymidylate Synthase (12)
Human (5)
Mouse (1)
Rat (1)
Bovine (1)
Chicken (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Product Group
DevKit DuoPlus (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (9)
Antibody Pair and Standard (1)
No (12)
Plasma (5)
Serum (5)
Tissue Homogenates (2)
TS / Thymidylate Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
TS / Thymidylate Synthase ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
TS / Thymidylate Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
TS / Thymidylate Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
TS / Thymidylate Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
TS / Thymidylate Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
TS / Thymidylate Synthase ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
TS / Thymidylate Synthase ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
1 Plate/$783
TS / Thymidylate Synthase ELISA Kit
Select
Custom
96-Well Strip Plate
Bovine
1 Plate/$783
TS / Thymidylate Synthase ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
1 Plate/$783
TS / Thymidylate Synthase ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
500 Wells/$1,120; 1000 Wells/$1,642
TS / Thymidylate Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Viewing 1-12 of 12 product results


Filtered By:
Products: ELISA Kits


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).