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TS / Thymidylate Synthase

thymidylate synthetase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Gene Name: thymidylate synthetase
Synonyms: TYMS, HST422, Thymidylate synthetase, TMS, TS, Thymidylate synthase, Tsase
Target Sequences: NM_001071 NP_001062.1 P04818

Publications (2)

1
Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. Haqqani AS, Cowling RT, Maroun JA, Birnboim HC. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1999 47:1563-74. [PubMed:10567440]
2
Calpain 9 as a therapeutic target in TGFß-induced mesenchymal transition and fibrosis. David H Kim, James D Beckett, Varun Nagpal, Manuel A Seman-Senderos, Russell A Gould, Tyler J Creamer, Elena Gallo MacFarlane, Yichun Chen, Djahida Bedja, Jonathan T Butcher, Wayne Mitzner, Rosanne Rouf, Shoji Hata, Daniel S Warren, Harry C Dietz. Science translational medicine. 2019 Jul;11:eaau2814. [Full Text Article] [PubMed:31316008] [PMC:PMC7351287] Related Antibodies: LS-C133503.

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TS / Thymidylate Synthase (100)
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TS / Thymidylate Synthase Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (OTI2C3) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
TS / Thymidylate Synthase Antibody - Immunofluorescence of monoclonal antibody to TYMS on HeLa cell. [antibody concentration 20 ug/ml]
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (3A1) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
TS / Thymidylate Synthase Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (3F1) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
TS / Thymidylate Synthase Antibody - Anti-TYMS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TS / Thymidylate Synthase Sheep anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$440
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$748
TS / Thymidylate Synthase Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (10F12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TS / Thymidylate Synthase Antibody - Detection of Human and Mouse TS by Western Blot. Samples: Whole cell lysate (50 ug) from Jurkat, 293T, HeLa, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-TS antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
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TS / Thymidylate Synthase Rabbit anti-Human Polyclonal (aa263-313) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
TS / Thymidylate Synthase Antibody - TYSY Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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TS / Thymidylate Synthase Rabbit anti-Human Polyclonal (aa265-294) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
500 µl/$890
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$832
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
HRP Conjugated
100 µl/$1,054
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Biotin Conjugated
100 µl/$1,054
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
FITC Conjugated
100 µl/$1,054
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
APC Conjugated
100 µl/$1,054
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
PE Conjugated
100 µl/$1,054
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF, WB
Unconjugated
50 µl/$303; 100 µl/$365
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715).
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (TMS715) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$371; 100 µg/$574
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715). This image was taken for the unmodified form of this product. Other forms have not been tested.
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Ready-to-Use) (TMS715) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Ready-to-Use
7 ml/$574
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715). This image was taken for the unmodified form of this product. Other forms have not been tested.
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TMS715) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with anti-Thymidylate Synthase antibody (SPM453).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (SPM453) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with anti-Thymidylate Synthase antibody (SPM453).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM453) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
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TS / Thymidylate Synthase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$973
TS / Thymidylate Synthase Antibody - Anti-TYMS/TS/Thymidylate Synthase antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TS / Thymidylate Synthase Sheep anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
500 µl/$615
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TS / Thymidylate Synthase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
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TS / Thymidylate Synthase Sheep anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$973
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).