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TRPV6

transient receptor potential cation channel, subfamily V, member 6

Calcium selective cation channel probably involved in Ca2+ uptake in various tissues, including Ca2+ reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca2+-dependent and a slower Ca2+-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg2+ in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.

Gene Name: transient receptor potential cation channel, subfamily V, member 6
Family/Subfamily: Ion Channel , Calcium channel - TRP
Synonyms: TRPV6, ABP/ZF, CAT1, CaT-L, CATL, Calcium transport protein 1, Epithelial calcium channel 2, ECAC2, HSA277909, ZFAB, Calcium channel CaT1, Calcium transporter 1, CaT-like, LP6728
Target Sequences: NM_018646 NP_061116.4 Q9H1D0

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
TRPV6 (3)
No (3)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
TRPV6 Protein - Recombinant Transient Receptor Potential Cation Channel Subfamily V, Member 6 By SDS-PAGE
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E. coli
His-T7
21.2 kDa
10 µg/$272; 50 µg/$387; 100 µg/$620; 200 µg/$772; 1 mg/$1,834; 500 µg/$1,393; 5 mg/$3,089
TRPV6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
83 kDa
100 µg/$710
TRPV6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
83 kDa
20 µg/$215
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).