Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
|Gene Name:||transient receptor potential cation channel, subfamily V, member 3|
|Family/Subfamily:||Ion Channel , Calcium channel - TRP|
|Synonyms:||TRPV3, OLMS, VRL-3, VRL3, Vanilloid receptor-like 3|
|Target Sequences:||NM_145068 NP_659505.1 Q8NET8|
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