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TRPM7
transient receptor potential cation channel, subfamily M, member 7
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
| Gene Name: | transient receptor potential cation channel, subfamily M, member 7 |
| Family/Subfamily: | Protein Kinase , Alpha-kinases |
| Synonyms: | TRPM7, CHAK, LTRPC7, ALSPDC, TRP-PLIK, CHAK1, Channel-kinase 1, LTrpC-7 |
| Target Sequences: | AF346629 AAK19738.2 Q96QT4 |
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