TRPM4

transient receptor potential cation channel, subfamily M, member 4

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

☰ Filters

Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

TRPM4 (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

Select

Human TRPM4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70377

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

134.1 kDa

Price:

20 µg/$1,107

Select

Human TRPM4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86929

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

134.1 kDa

Price:

20 µg/$215

Select

TRPM4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112311

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

134.1 kDa

Price:

100 µg/$710

Viewing 1-3 of 3 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.