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TRPM2

transient receptor potential cation channel, subfamily M, member 2

Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.

Gene Name: transient receptor potential cation channel, subfamily M, member 2
Family/Subfamily: Ion Channel , Calcium channel - TRP
Synonyms: TRPM2, EREG1, LTrpC-2, LTRPC2, NUDT9L1, KNP3, NUDT9H, Trrp7
Target Sequences: NM_003307 NP_003298.1 O94759

Publications (5)

1
Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. Bai JZ, Lipski J. Neurotoxicology. 2010 31:204-14. [PubMed:20064552]
2
Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. Chung KK, Freestone PS, Lipski J. Journal of neurophysiology. 2011 106:2865-75. (ICC, IHC-Fr; Rat) [PubMed:21900507]
3
TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation. Melzer N, Hicking G, Gbel K, Wiendl H. PloS one. 2012 7:e47617. (ICC; Mouse) [PubMed:23077651] [PMC:PMC3470594]
4
TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Tseng HH, Vong CT, Kwan YW, Lee SM, Hoi MP. Scientific reports. 2016 6:35016. (IHC, WB, IHC-P; Human) [Full Text Article] [PubMed:27731349] [PMC:PMC5059733] Related Antibodies: LS-B4122.
5
Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. Zhong J, Amina S, Liang M, Akther S, Yuhi T, Nishimura T, Tsuji C, Tsuji T, Liu HX, Hashii M, Furuhara K, Yokoyama S, Yamamoto Y, Okamoto H, Zhao YJ, Lee HC, Tominaga M, Lopatina O, Higashida H. Frontiers in neuroscience. 2016 10:304. (ICC; Rat) [Full Text Article] [PubMed:27499729] [PMC:PMC4956647] Related Antibodies: LS-C141843.
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Antibodies (30)
Primary (30)
TRPM2 (30)
Human (20)
Mouse (18)
Rat (14)
Guinea pig (3)
Monkey (1)
IHC (19)
IHC-P (10)
WB (24)
ELISA (6)
ICC (5)
IF (9)
IP (4)
Peptide-ELISA (2)
rabbit (29)
goat (1)
Product Group
IHCPlus (3)
IgG (18)
polyclonal pc (30)
Biotin Conjugated (4)
DY488 Conjugated (2)
DY550 Conjugated (2)
DY650 Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (16)
C-Terminus (5)
Internal (5)
aa431-480 (4)
aa1204-1503 (2)
aa1139-1150 (1)
aa1200-1250 (1)
aa181-423 (1)
aa60-119 (1)
aa650-700 (1)
No (28)
Yes (2)
TRPM2 Antibody - Anti-TRPM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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IHC-plus™ TRPM2 Antibody (aa1139-1150) LS-B4122
(5.0) Rating
(1) Publication(s)
TRPM2 Goat anti-Human Polyclonal (aa1139-1150) Antibody
Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
TRPM2 Antibody - TRPM2 antibody - Staining of rat hippocampus. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (C-Terminus) LS-C141843
(4.0) Rating
(1) Publication(s)
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat
ICC, IF, IHC, WB
Unconjugated
0.1 ml/$386
TRPM2 Antibody - TRPM2 antibody - Staining of rat hippocampus. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (C-Terminus, Biotin) LS-C141844
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Rat
ICC, IF, IHC, WB
Biotin Conjugated
0.1 ml/$416
TRPM2 Antibody - TRPM2 antibody - Staining of rat hippocampus. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (C-Terminus, DY550) LS-C141848
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) (DY550) Antibody
Mouse, Rat
ICC, IF, IHC, WB
DY550 Conjugated
0.1 ml/$416
TRPM2 Antibody - TRPM2 antibody - Staining of rat hippocampus. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (C-Terminus, DY650) LS-C141845
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) (DY650) Antibody
Mouse, Rat
ICC, IF, IHC, WB
DY650 Conjugated
0.1 ml/$416
TRPM2 Antibody - TRPM2 antibody - Staining of rat hippocampus. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (C-Terminus, DY488) LS-C141846
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) (DY488) Antibody
Mouse, Rat
ICC, IF, IHC, WB
DY488 Conjugated
0.1 ml/$416
TRPM2 Antibody - Anti-TRPM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (aa431-480) LS-B4013
TRPM2 Rabbit anti-Human Polyclonal (aa431-480) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TRPM2 Antibody - Anti-TRPM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (aa431-480, HRP) LS-C446485
TRPM2 Rabbit anti-Human Polyclonal (aa431-480) (HRP) Antibody
Mouse, Guinea pig, Rat, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
TRPM2 Antibody - Anti-TRPM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (aa431-480, Biotin) LS-C446483
TRPM2 Rabbit anti-Human Polyclonal (aa431-480) (Biotin) Antibody
Mouse, Guinea pig, Rat, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TRPM2 Antibody - Anti-TRPM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (aa431-480, FITC) LS-C446484
TRPM2 Rabbit anti-Human Polyclonal (aa431-480) (FITC) Antibody
Mouse, Guinea pig, Rat, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
TRPM2 Antibody - Immunohistochemistry of paraffin-embedded human tonsil tissue using antibody 1:100 dilution.
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TRPM2 Antibody (aa1204-1503) LS-C376950
TRPM2 Rabbit anti-Human Polyclonal (aa1204-1503) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
TRPM2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using antibody at dilution of 1:100.
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TRPM2 Antibody (aa60-119) LS-C395825
TRPM2 Rabbit anti-Human Polyclonal (aa60-119) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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TRPM2 Antibody LS-C89809
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IF, IP, WB
Unconjugated
100 µg/$865
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TRPM2 Antibody LS-C10881
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µg/$508
TRPM2 Antibody - IHC of paraffin-embedded MDAMB468 xenograft using TRPM2 antibody at 1:100 dilution.
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TRPM2 Antibody (aa181-423) LS-C186254
TRPM2 Rabbit anti-Human Polyclonal (aa181-423) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
TRPM2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IHC-plus™ TRPM2 Antibody (aa1200-1250) LS-B12396
(4.0) Rating
TRPM2 Rabbit anti-Human Polyclonal (aa1200-1250) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
TRPM2 Antibody - Detection of TRPM2 in mouse brain membrane lysates. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (Internal) LS-C141855
TRPM2 Rabbit anti-Mouse Polyclonal (Internal) Antibody
Mouse, Rat
WB
Unconjugated
0.1 ml/$386
TRPM2 Antibody - Detection of TRPM2 in mouse brain membrane lysates. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (Internal, Biotin) LS-C141856
TRPM2 Rabbit anti-Mouse Polyclonal (Internal) (Biotin) Antibody
Mouse, Rat
WB
Biotin Conjugated
0.1 ml/$416
TRPM2 Antibody - Detection of TRPM2 in mouse brain membrane lysates. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPM2 Antibody (Internal, DY650) LS-C141857
TRPM2 Rabbit anti-Mouse Polyclonal (Internal) (DY650) Antibody
Mouse, Rat
WB
DY650 Conjugated
0.1 ml/$416
TRPM2 Antibody - Immunofluorescence analysis of HeLa cells.
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TRPM2 Antibody LS-C346101
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TRPM2 Antibody - 1:100 staining human brain carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TRPM2 Antibody LS-C809690
TRPM2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TRPM2 Antibody - Immunohistochemistry of paraffin-embedded human pancreas tissue using antibody at 1:100 dilution.
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TRPM2 Antibody (aa1204-1503) LS-C376944
TRPM2 Rabbit anti-Human Polyclonal (aa1204-1503) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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TRPM2 Antibody LS-C341936
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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TRPM2 Antibody (aa650-700) LS-C287307
TRPM2 Rabbit anti-Human Polyclonal (aa650-700) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$520
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TRPM2 Antibody LS-C771454
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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