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TRPC3
transient receptor potential cation channel, subfamily C, member 3
The transient receptor potential canonical (TRPC) group of channels, including TPRC3, is a family of receptor-activated non-selective calcium permeant cation channels. In vitro TRPC proteins can form hetero- or homo-oligomeric channels. Endogenous TRPC1, TRPC3 and TRPC7 participate in forming heteromeric store-operated channels, while TRPC3 and TRPC7 can also participate in forming heteromeric receptor-operated channels. TRPC3 plays important roles in neuronal differentiation and immune cell maturation by mediating the cationic current in response to phospholipase C activation, Ca(2+) depletion, and diacylglycerol stimulation. TRPC3 channels are highly expressed in pontine neurons and mediate a nonselective cation current in response to the neurotrophin receptor, TrkB.
| Gene Name: | transient receptor potential cation channel, subfamily C, member 3 |
| Family/Subfamily: | Ion Channel , Calcium channel - TRP |
| Synonyms: | TRPC3, HTrp-3, HTrp3, TRP3, Transient receptor protein 3, TRP-3, Trrp3 |
| Target Sequences: | NM_003305 NP_003296.1 Q13507 |
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