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Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Gene Name: | tRNA methyltransferase 5 |
Synonyms: | TRMT5, KIAA1393, M1G-methyltransferase, TRM5, TRNA [GM37] methyltransferase, TRNA-N1G37 methyltransferase |
Target Sequences: | Q32P41 Q32P41 |
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