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TRIP13
thyroid hormone receptor interactor 13
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes.
| Gene Name: | thyroid hormone receptor interactor 13 |
| Synonyms: | TRIP13, 16E1-BP, 16E1BP, TR-interacting protein 13, TRIP-13, PCH2 |
| Target Sequences: | NM_004237 NP_004228.1 Q15645 |
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