TRIP12

thyroid hormone receptor interactor 12

E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

☰ Filters

Products

Antibodies (9)

Proteins (2)

Type

Primary (9)

Recombinant (2)

Target

TRIP12 (11)

Reactivity

Human (9)

Mouse (2)

Rat (2)

Application

IHC (4)

IHC-P (4)

WB (7)

ELISA (3)

IF (1)

IP (1)

Peptide-ELISA (1)

Host

rabbit (9)

Product Group

IHCPlus (3)

Isotype

IgG (5)

Clonality

polyclonal pc (9)

Format

Unconjugated (9)

Epitope

aa75-125 (1)

aa991-1023 (1)

Publications

No (11)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST, N-terminus (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

IHC-plus™ TRIP12 Antibody LS-B7823

(4.0) Rating

Antibody:

TRIP12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

IHC-plus™ TRIP12 Antibody LS-B12129

(4.0) Rating

Antibody:

TRIP12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

IHC-plus™ TRIP12 Antibody (aa75-125) LS-B12675

(4.0) Rating

Antibody:

TRIP12 Rabbit anti-Human Polyclonal (aa75-125) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

TRIP12 Antibody LS-C668051

Antibody:

TRIP12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

Human TRIP12 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G61067

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human TRIP12 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) - LS-G137340

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

19.9 kDa

Price:

20 µg/$364; 1 mg/$1,679; 100 µg/$500

Select

TRIP12 Antibody LS-C676649

Antibody:

TRIP12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

TRIP12 Antibody LS-C778691

Antibody:

TRIP12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

TRIP12 Antibody (aa991-1023) LS-C392975

Antibody:

TRIP12 Rabbit anti-Human Polyclonal (aa991-1023) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

TRIP12 Antibody LS-C771433

Antibody:

TRIP12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

TRIP12 Antibody LS-C498068

Antibody:

TRIP12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Viewing 1-11 of 11 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.