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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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TRIP10 / CIP4
thyroid hormone receptor interactor 10
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling By similarity. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
| Gene Name: | thyroid hormone receptor interactor 10 |
| Synonyms: | TRIP10, Cdc42-interacting protein 4, Protein Felic, Salt tolerator, STOT, STP, TR-interacting protein 10, Salt tolerant protein, CIP4, HSTP, TRIP-10 |
| Target Sequences: | NM_004240 NP_004231.1 Q15642 |
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