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TRIOBP
TRIO and F-actin binding protein
TRIOBP is a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).
| Gene Name: | TRIO and F-actin binding protein |
| Synonyms: | TRIOBP, DJ37E16.4, DFNB28, KIAA1662, HRIHFB2122, Protein Tara, Tara-like protein, TARA |
| Target Sequences: | NM_007032 NP_008963.3 Q9H2D6 |
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