Trimethylguanosine Synthase 1

trimethylguanosine synthase 1

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

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Proteins (3)

Type

Recombinant (3)

Target

Trimethylguanosine Synthase 1 (3)

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No (3)

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GST (2)

His-SUMO (1)

Species

Human (3)

Source

E. coli (1)

Wheat Germ Extract (1)

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Purified (1)

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Human Trimethylguanosine Synthase 1 Protein (Recombinant GST) (Full Length) - LS-G132221

Tag:

GST

Molecular Weight:

120.3kDa

Price:

2 µg/$439

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Human Trimethylguanosine Synthase 1 Protein (Recombinant His-SUMO) (aa713-853) - LS-G21861

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

31.64 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human Trimethylguanosine Synthase 1 Protein (Recombinant GST) (Full Length) - LS-G36120

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.25 kDa

Price:

10 µg/$479; 25 µg/$670

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