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TRIM68
tripartite motif containing 68
TRIM68 is a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants.
| Gene Name: | tripartite motif containing 68 |
| Family/Subfamily: | Tripartite Motif |
| Synonyms: | TRIM68, GC109, RNF137, Ro/SSA1 related protein, SS-56, Tripartite motif containing 68, RING finger protein 137, SS56, Tripartite motif-containing 68, SSA protein SS-56 |
| Target Sequences: | NM_018073 NP_060543.5 Q6AZZ1 |
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