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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TRIM5

tripartite motif containing 5

TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the a variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). Expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. All TRIM5a variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5a acts as a natural barrier to cross-species retrovirus transmission (3). While a function has not yet been assigned to TRIM5g, it is known that expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enable resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. Furthermore, the TRIM5d isoform appears to serve as a scaffold for the assembly of endogenous BTBD1 and BTBD2 proteins and also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner. The TRIM5d isoform has been shown to colocalize with the topoisomerase I-interacting proteins BTBD1 and BTBD2 in punctate or elongated cytoplasmic bodies in several mouse and human cells where it appears to serve as a scaffold for the assembly of endogenous BTBD proteins. TRIM5d also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner.

Gene Name: tripartite motif containing 5
Family/Subfamily: Tripartite Motif
Synonyms: TRIM5, RNF88, RING finger protein 88, Tripartite motif containing 5, TRIM5alpha, Tripartite motif protein TRIM5, Tripartite motif-containing 5
Target Sequences: NM_033034

Filtered by: None
Target
TRIM5 (36)
Reactivity
Human (36)
Mouse (4)
Rat (2)
Chimpanzee (3)
Monkey (1)
Application
IHC (10)
IHC-P (7)
WB (32)
ELISA (19)
IF (4)
Peptide-ELISA (2)
Host
rabbit (31)
mouse (3)
goat (2)
Isotype
IgG (24)
IgG1 (3)
Clonality
monoclonal mc (3)
polyclonal pc (33)
Clone
3B11H2 (2)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (24)
Epitope
aa371-399 (8)
aa35-84 (4)
C-Terminus (3)
aa2-15 (1)
aa386-396 (1)
Publications
No (36)
Showing 1-25 of 36 results

IHC-plus™ TRIM5 Antibody LS-B610
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $545.00
Anti-TRIM5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Immunofluorescence of TRIM5 alpha in Human Stomach cells with TRIM5 alpha antibody at 10 ug/ml.

IHC-plus™ TRIM5 Antibody LS-B3198
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $545.00
Anti-TRIM5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TRIM5 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

TRIM5 Antibody LS-C353
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IF, WB
Unconjugated
0.1mg 1mg/ml  $365.00
Immunofluorescence of TRIM5a in human breast tissue with TRIM5a antibody at 10 µg/ml.
Western blot of TRIM5a expression in human stomach (A), thymus (B), and uterus (C) cell lysate with TRIM5a antibody at 2 ug /ml.

IHC-plus™ TRIM5 Antibody (aa2-15) LS-B2562
Goat Polyclonal to Human TRIM5
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg  $425.00
Anti-TRIM5 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-TRIM5 / RNF88 Antibody (2µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer). Detected by chemiluminescencence.

TRIM5 Antibody LS-C351
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IF, IHC-P, WB
Unconjugated
0.1mg 1mg/ml  $365.00
Immunohistochemistry of TRIM5 delta in mouse brain tissue with TRIM5 delta antibody at 1 ug/mL.
Immunofluorescence of TRIM5 delta in mouse brain tissue with TRIM5 delta antibody at 10 ug/mL.

TRIM5 Antibody LS-C679898
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human pancreatic tissue at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution of 1:100

IHC-plus™ TRIM5 Antibody LS-B3787
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-TRIM5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TRIM5 antibody IHC of human prostate, stroma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

TRIM5 Antibody LS-C802016
Mouse Monoclonal (IgG1) to Human TRIM5
Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $315.00; 100µl 1mg/ml  $375.00; 200µl 1mg/ml  $435.00

TRIM5 Antibody LS-C661265
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IHC, WB
Unconjugated
100µg  $465.00

TRIM5 Antibody (clone 3B11H2) LS-C758486
Mouse Monoclonal [clone 3B11H2] (IgG1) to Human TRIM5
Human
IHC, WB
Unconjugated
100µl  $405.00
TRIM5 alpha Antibody in Immunohistochemistry (IHC)
TRIM5 alpha Antibody in Western Blot (WB)

TRIM5 Antibody (clone 3B11H2) LS-C47147
Mouse Monoclonal [clone 3B11H2] (IgG1) to Human TRIM5
Human
IHC, WB
Unconjugated
100µg  $365.00
Immunohistochemistry Image
Western blot Image

TRIM5 Antibody LS-C412304
Rabbit Polyclonal to Human TRIM5
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl  $385.00

TRIM5 Antibody (aa371-399) LS-C325962
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
Unconjugated
200µl  $590.00

TRIM5 Antibody (aa371-399, Biotin) LS-C272235
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

TRIM5 Antibody (aa371-399, FITC) LS-C272237
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
FITC Conjugated
200µl  $740.00

TRIM5 Antibody (aa371-399, APC) LS-C272236
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
APC Conjugated
200µl  $740.00

TRIM5 Antibody (aa371-399, PE) LS-C272243
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
PE Conjugated
200µl  $740.00

TRIM5 Antibody (aa371-399, Azide-free, HRP) LS-C272238
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl  $740.00

TRIM5 Antibody (aa371-399, AP) LS-C272234
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
AP Conjugated
200µl  $740.00

TRIM5 Antibody LS-C662524
Rabbit Polyclonal to Human TRIM5
Human
ELISA, WB
Unconjugated
100µg  $325.00
Western blot - Anti-TRIM5 Picoband antibody

TRIM5 Antibody (aa386-396) LS-C55627
Goat Polyclonal to Human TRIM5
Human
IHC-P, Peptide-ELISA
Unconjugated
100µg 0.5mg/ml  $405.00
Goat Anti-TRIM5 / RNF88 (alpha isoform) Antibody (4µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.

TRIM5 Antibody LS-C771426
Rabbit Polyclonal (IgG) to Human TRIM5
Mouse, Human
WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

TRIM5 Antibody LS-C39849
Rabbit Polyclonal (IgG) to Human TRIM5
Human
WB
Unconjugated
100µg  $530.00

TRIM5 Antibody (C-Terminus) LS-C39850
Rabbit Polyclonal (IgG) to Human TRIM5
Human
WB
Unconjugated
100µg  $530.00

TRIM5 Antibody (C-Terminus) LS-C39852
Rabbit Polyclonal (IgG) to Human TRIM5
Mouse, Rat, Human
WB
Unconjugated
100µg  $530.00
Showing 1-25 of 36 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).