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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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TRIM5

tripartite motif containing 5

TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the a variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). Expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. All TRIM5a variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5a acts as a natural barrier to cross-species retrovirus transmission (3). While a function has not yet been assigned to TRIM5g, it is known that expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enable resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. Furthermore, the TRIM5d isoform appears to serve as a scaffold for the assembly of endogenous BTBD1 and BTBD2 proteins and also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner. The TRIM5d isoform has been shown to colocalize with the topoisomerase I-interacting proteins BTBD1 and BTBD2 in punctate or elongated cytoplasmic bodies in several mouse and human cells where it appears to serve as a scaffold for the assembly of endogenous BTBD proteins. TRIM5d also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner.

Gene Name: tripartite motif containing 5
Family/Subfamily: Tripartite Motif
Synonyms: TRIM5, RNF88, RING finger protein 88, Tripartite motif containing 5, TRIM5alpha, Tripartite motif protein TRIM5, Tripartite motif-containing 5
Target Sequences: NM_033034


TRIM5 Antibody - Anti-TRIM5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
TRIM5 Antibody - Anti-TRIM5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
TRIM5 Antibody - Anti-TRIM5 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Human TRIM5
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   $425.00
TRIM5 Antibody - Anti-TRIM5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
TRIM5 Antibody - Immunofluorescence of TRIM5a in human breast tissue with TRIM5a antibody at 10 µg/ml.
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Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IF, WB
Unconjugated
0.1mg   1mg/ml   $375.00
TRIM5 Antibody - Immunohistochemistry of TRIM5 delta in mouse brain tissue with TRIM5 delta antibody at 1 ug/mL.
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Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IF, IHC-P, WB
Unconjugated
0.1mg   1mg/ml   $375.00
TRIM5 Antibody - Immunohistochemistry of paraffin-embedded human pancreatic tissue at dilution of 1:100
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Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Mouse Monoclonal (IgG1) to Human TRIM5
Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
TRIM5 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded human metastatic adenocarcinoma(A) and stomach adenocarcinoma (B), showing cytoplasmic localization with AEC staining (A) and DAB staining(B) using TRIM5alpha Monoclonal Antibody.
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Mouse Monoclonal (IgG1) to Human TRIM5
Human
ELISA, IHC, WB
Unconjugated
100µl   $345.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, IHC, WB
Unconjugated
100µg   $465.00
TRIM5 Antibody - TRIM5 alpha Antibody in Immunohistochemistry (IHC)
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Mouse Monoclonal [clone 3B11H2] (IgG1) to Human TRIM5
Human
IHC, WB
Unconjugated
100µl   $425.00
TRIM5 Antibody
Select
Mouse Monoclonal [clone 3B11H2] (IgG1) to Human TRIM5
Human
IHC, WB
Unconjugated
100µg   $365.00
Select
Rabbit Polyclonal to Human TRIM5
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
ELISA, WB
APC Conjugated
200µl   $740.00
TRIM5 Antibody - Western blot - Anti-TRIM5 Picoband antibody
Select
Rabbit Polyclonal to Human TRIM5
Human
ELISA, WB
Unconjugated
100µg   $325.00
TRIM5 Antibody - Goat Anti-TRIM5 / RNF88 (alpha isoform) Antibody (4µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
Select
Goat Polyclonal to Human TRIM5
Human
IHC-P, Peptide-ELISA
Unconjugated
100µg   0.5mg/ml   $405.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
WB
Unconjugated
100µg   $530.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Human
WB
Unconjugated
100µg   $530.00
Select
Rabbit Polyclonal (IgG) to Human TRIM5
Mouse, Rat, Human
WB
Unconjugated
100µg   $530.00
Viewing 1-25 of 38 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).