TRIM27

tripartite motif containing 27

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

TRIM27 (3)

Publications

No (3)

Tag

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

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Human TRIM27 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88122

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.3 kDa

Price:

20 µg/$150

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Human TRIM27 Protein (Recombinant His, N-Terminal) - LS-G143882

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

58.5 kDa

Price:

50 µg/$419

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TRIM27 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100835

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.3 kDa

Price:

100 µg/$494

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