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TRIM27

tripartite motif containing 27

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Gene Name: tripartite motif containing 27
Family/Subfamily: Tripartite Motif
Synonyms: TRIM27, Ret finger protein, Tripartite motif-containing 27, Zinc finger protein RFP, RFP transforming protein, RING finger protein 76, RNF76, Tripartite motif containing 27, RFP
Target Sequences: NM_006510 NP_006501.1 P14373

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Products
Antibodies (30)
Primary (30)
TRIM27 (30)
Human (29)
Mouse (12)
Rat (8)
Bovine (6)
Chimpanzee (6)
Dog (6)
Gibbon (6)
Horse (6)
Monkey (7)
Pig (6)
Rabbit (6)
IHC (11)
IHC-P (3)
WB (28)
ELISA (10)
IF (2)
IP (1)
Peptide-ELISA (1)
rabbit (23)
mouse (7)
IgG (18)
IgG1 (7)
monoclonal mc (7)
polyclonal pc (23)
OTI2F9 (2)
OTI3B12 (2)
OTI4D4 (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
Carrier-free (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (19)
aa453-482 (7)
aa141-190 (4)
aa151-200 (4)
aa214-513 (1)
No (30)
TRIM27 Antibody - Immunohistochemistry of paraffin-embedded human rectal cancer using antibody at 1:100 dilution.
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TRIM27 Rabbit anti-Human Polyclonal (aa214-513) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
TRIM27 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TRIM27 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TRIM27 Mouse anti-Human Monoclonal (OTI4D4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRIM27 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TRIM27 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TRIM27 Mouse anti-Human Monoclonal (Carrier-free) (OTI4D4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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TRIM27 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
TRIM27 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer tissue  using TRIM27 Polyclonal Antibody at dilution of 1:65(×200)
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TRIM27 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TRIM27 Antibody - Immunofluorescence analysis of U2OS cells.
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TRIM27 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TRIM27 Antibody - Immunohistochemistry of paraffin-embedded Human esophagus using TRIM27 Polyclonal Antibody at dilution of 1:100 (40x lens).
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TRIM27 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TRIM27 Antibody - Immunohistochemistry of paraffin-embedded Human brain tissue  using TRIM27 Polyclonal Antibody at dilution of 1:45(×200)
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TRIM27 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TRIM27 Antibody - IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-TRIM27 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TRIM27 Mouse anti-Human Monoclonal (OTI3B12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRIM27 Antibody - IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-TRIM27 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TRIM27 Mouse anti-Human Monoclonal (Carrier-free) (OTI3B12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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TRIM27 Rabbit anti-Human Polyclonal (aa453-482) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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TRIM27 Rabbit anti-Human Polyclonal (aa453-482) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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TRIM27 Rabbit anti-Human Polyclonal (aa453-482) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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TRIM27 Rabbit anti-Human Polyclonal (aa453-482) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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TRIM27 Rabbit anti-Human Polyclonal (aa453-482) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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TRIM27 Rabbit anti-Human Polyclonal (aa453-482) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
TRIM27 Antibody - Immunohistochemistry of paraffin-embedded Rat ovary using TRIM27 Polyclonal Antibody at dilution of 1:100 (40x lens).
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TRIM27 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TRIM27 Antibody - Western blot analysis of extracts of COS-7 cells using TRIM27 antibody. The lane on the left was treated with blocking peptide.
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TRIM27 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TRIM27 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRIM27 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRIM27.
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TRIM27 Mouse anti-Human Monoclonal (OTI2F9) Antibody
Human
WB
Unconjugated
100 µl/$434
TRIM27 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRIM27 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRIM27.
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TRIM27 Mouse anti-Human Monoclonal (Carrier-free) (OTI2F9) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
TRIM27 Antibody - Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRIM27 Rabbit anti-Human Polyclonal (aa151-200) Antibody
Human
WB
Unconjugated
100 µl/$424
TRIM27 Antibody - TRIM27 antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRIM27 Rabbit anti-Human Polyclonal (aa141-190) Antibody
Human
WB
Unconjugated
100 µl/$424
TRIM27 Antibody - TRIM27 antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRIM27 Rabbit anti-Human Polyclonal (aa141-190) (FITC) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
TRIM27 Antibody - TRIM27 Antibody western blot of K562 cell line lysates (35 ug/lane). The TRIM27 antibody detected the TRIM27 protein (arrow).
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TRIM27 Rabbit anti-Human Polyclonal (aa453-482) Antibody
Human
WB
Unconjugated
400 µl/$393
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TRIM27 Mouse Monoclonal Antibody
WB
Unconjugated
50 µl/$321; 100 µl/$403
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).