TRIM24 / TIF1

tripartite motif containing 24

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

TRIM24 / TIF1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (1)

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Human TRIM24 / TIF1 Protein (Recombinant His-SUMO) (aa891-1012) - LS-G21290

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

30.47 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human TRIM24 / TIF1 Protein (Recombinant GST) (Full Length) - LS-G31338

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

143.2 kDa

Price:

10 µg/$479; 25 µg/$670

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TRIM24 / TIF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113008

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.8 kDa

Price:

100 µg/$494

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Human TRIM24 / TIF1 Protein (Recombinant His) (aa891-1012) - LS-G23175

Source:

Yeast

Tag:

His

Molecular Weight:

16.48 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human TRIM24 / TIF1 Protein (Recombinant GST, N-terminus) (aa432-569) - LS-G60875

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TRIM24 / TIF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80149

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.8 kDa

Price:

20 µg/$150

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