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TRIM24 / TIF1

tripartite motif containing 24

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes.

Gene Name: tripartite motif containing 24
Family/Subfamily: Tripartite Motif , TIF1
Synonyms: TRIM24, TF1A, TIF1, TIF1A, Tripartite motif-containing 24, TIF1ALPHA, PTC6, RNF82, TIF1-alpha, Tripartite motif containing 24, HTIF1, RING finger protein 82
Target Sequences: AF119042 AAD17258.1 O15164

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Products
Antibodies (50)
Primary (50)
TRIM24 / TIF1 (50)
Human (49)
Mouse (15)
Rat (7)
Bat (6)
Bovine (8)
Chimpanzee (6)
Dog (1)
Gibbon (6)
Guinea pig (6)
Horse (7)
Monkey (8)
Pig (5)
Rabbit (6)
IHC (16)
IHC-P (7)
WB (48)
ChIP-Seq (1)
ELISA (12)
ICC (1)
IF (4)
IP (4)
Peptide-ELISA (4)
rabbit (34)
mouse (15)
goat (1)
Product Group
IHCPlus (2)
IgG (20)
IgG1 (14)
IgG3,k (1)
monoclonal mc (15)
polyclonal pc (35)
2F2 (1)
OTI1A2 (2)
OTI1D1 (2)
OTI1D4 (2)
OTI1G5 (2)
OTI2D9 (2)
OTI2H1 (2)
OTI3A8 (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
Carrier-free (7)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (39)
aa706-1016 (14)
aa16-45 (7)
C-Terminus (5)
aa503-552 (4)
aa700-750 (2)
960-1040 aa, C-terminal (1)
Gln1034 (1)
aa1000-C-term (1)
aa1001-1050 (1)
aa1038-1050 (1)
aa789-843 (1)
aa985-1034 (1)
No (50)
TRIM24 / TIF1 Antibody - Immunoperoxidase of monoclonal antibody to TRIM24 on formalin-fixed paraffin-embedded human testis. [antibody concentration 6 ug/ml]
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TRIM24 / TIF1 Mouse anti-Human Monoclonal (2F2) Antibody
Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$423
TRIM24 / TIF1 Antibody - Anti-TRIM24 / TIF1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa1001-1050) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
TRIM24 / TIF1 Antibody - 1:100 staining human lymph node tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
TRIM24 / TIF1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TRIM24 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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TRIM24 / TIF1 Mouse anti-Human Monoclonal (aa706-1016) (OTI2D9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRIM24 / TIF1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TRIM24 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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TRIM24 / TIF1 Mouse anti-Human Monoclonal (aa706-1016) (Carrier-free) (OTI2D9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TRIM24 / TIF1 Antibody - Detection of Human TIF1 alpha/TRIM24 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-TIF1 alpha/TRIM24 used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa700-750) Antibody
Mouse, Human
ChIP-Seq, IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TRIM24 / TIF1 Antibody - Western blot of TIF1alpha antibody
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (960-1040 aa, C-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TRIM24 / TIF1 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using TRIM24 antibody.
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
TRIM24 / TIF1 Antibody - Western blot analysis of the lysates from HepG2 cells using TRIM24 antibody.
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa985-1034) Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TRIM24 / TIF1 Antibody - Immunohistochemical analysis of TIF1 alpha staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Bovine, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$299
TRIM24 / TIF1 Antibody - IHC of TIF1 (Q1034) pAb in paraffin-embedded human brain tissue.
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (Gln1034) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
TRIM24 / TIF1 Antibody - Western blot of Jurkat and K562 cell lysate using TRIM24 Antibody
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa16-45) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa16-45) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa16-45) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa16-45) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa16-45) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa16-45) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa1000-C-term) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
TRIM24 / TIF1 Antibody - Detection of Human TIF1 Alpha / TRIM24 by Immunohistochemistry. Sample: FFPE section of human breast tumor. Antibody: Affinity purified rabbit anti-TIF1 Alpha/TRIM24 used at a dilution of 1:250.
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TRIM24 / TIF1 Rabbit anti-Human Polyclonal (aa700-750) Antibody
Mouse, Human
IHC
Unconjugated
1 µg/$295; 100 µl/$532
TRIM24 / TIF1 Antibody - Western blot of lysates from mouse NIH/3T3 cell line, mouse spleen, mouse testis, mouse thymus tissue lysate (from left to right) with Trim24 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.
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TRIM24 / TIF1 Rabbit anti-Mouse Polyclonal (aa789-843) Antibody
Mouse
WB
Unconjugated
400 µl/$393
TRIM24 / TIF1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRIM24 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRIM24.
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TRIM24 / TIF1 Mouse anti-Human Monoclonal (aa706-1016) (OTI3A8) Antibody
Human
WB
Unconjugated
100 µl/$434
TRIM24 / TIF1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRIM24 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRIM24.
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TRIM24 / TIF1 Mouse anti-Human Monoclonal (aa706-1016) (OTI2H1) Antibody
Human
WB
Unconjugated
100 µl/$434
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).