TRIM21 / RO52

tripartite motif containing 21

E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.

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Products

Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

TRIM21 / RO52 (12)

Application

SDS-PAGE (1)

Publications

No (12)

Tag

6His, N-terminus (3)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His,N-terminus (1)

His-SUMO (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Mouse (2)

Rat (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (5)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human TRIM21 / RO52 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G23174

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

56.17 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human TRIM21 / RO52 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G97063

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

58.2 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Mouse TRIM21 / RO52 Protein (Recombinant 6His, N-terminus) (Asp272-Met470) - LS-G133527

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

26.4kDa

Price:

10 µg/$263; 50 µg/$343; 200 µg/$662; 100 µg/$530; 1 mg/$1,657; 500 µg/$1,242; 5 mg/$2,600; 2 mg/$1,832

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Mouse TRIM21 / RO52 Protein (Recombinant His-SUMO) (Full Length) - LS-G21743

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

70.14 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human TRIM21 / RO52 Protein (Recombinant His,N-terminus) (Met1-Tyr475) - LS-G141204

Source:

Baculovirus

Tag:

His,N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human TRIM21 consists of 494 amino acids and predicts a molecular mass of 56.5 kDa.

Price:

100 µg/$519

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Human TRIM21 / RO52 Protein (Recombinant His-T7, N-terminus) (Glu268-Leu465) - LS-G133407

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

26.1kDa

Price:

10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Human TRIM21 / RO52 Protein (Recombinant GST, N-terminus) (aa68-175) - LS-G60210

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TRIM21 / RO52 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64768

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54 kDa

Price:

20 µg/$1,107

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Human TRIM21 / RO52 Protein (Recombinant GST) (Full Length) - LS-G30540

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

77.99 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TRIM21 / RO52 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74153

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54 kDa

Price:

20 µg/$150

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TRIM21 / RO52 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99974

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54 kDa

Price:

100 µg/$494

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Rat TRIM21 / RO52 Protein (Recombinant His, N-Terminal) (Asp272-Ile471) - LS-G133219

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

26.5kDa

Price:

10 µg/$265; 50 µg/$347; 200 µg/$682; 100 µg/$545; 1 mg/$1,690; 500 µg/$1,270; 5 mg/$2,637; 2 mg/$1,866

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