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TRIB2
tribbles pseudokinase 2
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
| Gene Name: | tribbles pseudokinase 2 |
| Synonyms: | TRIB2, C5FW, GS3955, TRB-2, TRB2, Tribbles homolog 2 |
| Target Sequences: | NM_021643 NP_067675.1 Q92519 |
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