TREX1

three prime repair exonuclease 1

Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

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Products

Antibodies (19)

Type

Primary (19)

Target

TREX1 (19)

Reactivity

Human (19)

Mouse (3)

Rat (2)

Application

IHC (4)

IHC-P (3)

WB (17)

ELISA (3)

ICC (1)

IF (4)

Host

rabbit (17)

mouse (2)

Isotype

IgG (7)

IgG2b,k (2)

Clonality

monoclonal mc (2)

polyclonal pc (17)

Clone

41M5F2 (1)

Format

APC (1)

APC Conjugated (1)

Biotin Conjugated (1)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (12)

Epitope

aa6-369 (8)

aa1-270 (2)

aa156-185 (1)

aa211-350 (1)

Publications

No (19)

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TREX1 Antibody (aa211-350, clone 41M5F2) LS-C359348

Antibody:

TREX1 Mouse anti-Human Monoclonal (aa211-350) (41M5F2) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$386

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TREX1 Antibody LS-C335702

Antibody:

TREX1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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TREX1 Antibody (aa1-270) LS-C379401

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa1-270) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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TREX1 Antibody LS-C82903

Antibody:

TREX1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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TREX1 Antibody (aa1-270) LS-C379400

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa1-270) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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TREX1 Antibody LS-C482708

Antibody:

TREX1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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TREX1 Antibody LS-C834375

Antibody:

TREX1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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TREX1 Antibody LS-C783129

Antibody:

TREX1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

25 µg/$288; 100 µg/$414

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TREX1 Antibody (aa156-185) LS-C407960

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa156-185) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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TREX1 Antibody LS-C490420

Antibody:

TREX1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$575

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TREX1 Antibody (aa6-369) LS-C374677

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa6-369) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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TREX1 Antibody (aa6-369, HRP) LS-C711938

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa6-369) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

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TREX1 Antibody (aa6-369, Biotin) LS-C687472

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa6-369) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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TREX1 Antibody (aa6-369, FITC) LS-C694303

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa6-369) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716

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TREX1 Antibody (aa6-369, APC) LS-C718046

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa6-369) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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TREX1 Antibody (aa6-369, PE) LS-C725999

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa6-369) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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TREX1 Antibody (aa6-369, APC, Cy7) LS-C734949

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa6-369) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676

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TREX1 Antibody (aa6-369, Cy3) LS-C702916

Antibody:

TREX1 Rabbit anti-Human Polyclonal (aa6-369) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE
• APC, Cy7
• More...
  • Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE
  • APC, Cy7
  • Cy3

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TREX1 Antibody LS-C661241

Antibody:

TREX1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Format:

Unconjugated

Price:

100 µg/$351

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