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TREM2 / TREM-2
triggering receptor expressed on myeloid cells 2
TREM2 / TREM-2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | triggering receptor expressed on myeloid cells 2 |
| Synonyms: | TREM2, Trem2b, TREM-2, Trem2a, Trem2c |
| Target Sequences: | NM_018965 NP_061838.1 Q9NZC2 |
Publications (3)
1
Dark microglia: A new phenotype predominantly associated with pathological states. Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gómez-Nicola D, Luheshi G, Vallières L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay MÈ. Glia. 2016 64:826-39. (IHC; Mouse)
[Full Text Article]
[PubMed:26847266]
[PMC:PMC4949554]
2
TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. Gonçalves LA, Rodrigues-Duarte L, Rodo J, Vieira de Moraes L, Marques I, Penha-Gonçalves C. Proceedings of the National Academy of Sciences of the United States of America. 2013 110:19531-6. (WB; Mouse)
[Full Text Article]
[PubMed:24218563]
Related Antibodies: LS-C272143.
3
microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration. Bhattacharjee S, Zhao Y, Dua P, Rogaev EI, Lukiw WJ. PloS one. 2016 March;11:e0150211. [Full Text Article]
[PubMed:26949937]
[PMC:PMC4780721]
☰ Filters
Products
Proteins
(17)
Type
Over-Expression Lysate
(2)
Recombinant
(15)
Target
TREM2 / TREM-2
(17)
Application
SDS-PAGE
(1)
Publications
No
(17)
Tag
6His, C-terminus
(4)
6His, N-terminus
(4)
Fc, C-terminus
(2)
GST
(1)
His
(2)
His,C-terminus
(1)
His-GST
(1)
Myc-DDK (Flag)
(2)
Species
Human
(9)
Mouse
(7)
Source
293T Cells
(1)
E. coli
(5)
HEK 293 Cells
(2)
Human Cells
(3)
Mammalian Cells
(4)
Wheat Germ Extract
(1)
Yeast
(1)
Purification
Purified
(8)
Low Endotoxin Level
Low endotoxin level
(8)
E. coli
His-GST
54.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Mammalian Cells
6His, N-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant human TREM2 comprises 167 amino acids with a predicted molecular mass of 18.9 kDa. As a result of glycosylation, the apparent molecular mass of rhTREM2 is approximately 30-40 kDa band in SDS-PAGE under reducing conditions.
100 µg/$441; 1 mg/$2,261
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.3kD
10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.3kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
HEK 293 Cells
Myc-DDK (Flag)
23.4 kDa
100 µg/$494
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.3 kDa
10 µg/$277; 50 µg/$389
Wheat Germ Extract
GST
50.16 kDa
10 µg/$479; 25 µg/$670
Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
293T Cells
Myc-DDK (Flag)
23.4 kDa
20 µg/$150
E. coli
155 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
17.16 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.3 kDa
10 µg/$281; 50 µg/$389
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.7 kDa
10 µg/$281; 50 µg/$389
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.7kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
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