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TREM2 / TREM-2

triggering receptor expressed on myeloid cells 2

TREM2 / TREM-2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: triggering receptor expressed on myeloid cells 2
Synonyms: TREM2, Trem2b, TREM-2, Trem2a, Trem2c
Target Sequences: NM_018965 NP_061838.1 Q9NZC2

Publications (3)

1
Dark microglia: A new phenotype predominantly associated with pathological states. Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gómez-Nicola D, Luheshi G, Vallières L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay MÈ. Glia. 2016 64:826-39. (IHC; Mouse) [Full Text Article] [PubMed:26847266] [PMC:PMC4949554]
2
TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. Gonçalves LA, Rodrigues-Duarte L, Rodo J, Vieira de Moraes L, Marques I, Penha-Gonçalves C. Proceedings of the National Academy of Sciences of the United States of America. 2013 110:19531-6. (WB; Mouse) [Full Text Article] [PubMed:24218563] Related Antibodies: LS-C272143.
3
microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration. Bhattacharjee S, Zhao Y, Dua P, Rogaev EI, Lukiw WJ. PloS one. 2016 March;11:e0150211. [Full Text Article] [PubMed:26949937] [PMC:PMC4780721]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).