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Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
|Gene Name:||tribbles pseudokinase 3|
|Synonyms:||TRIB3, C20orf97, NIPK, SINK, TRB-3, TRB3, DJ1103G7.3, SKIP3, Tribbles homolog 3|
|Target Sequences:||NM_021158 NP_066981.2 Q96RU7|
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